Tri‐Compartmental Restriction Spectrum Imaging Based on 18 F‐FDG PET / MR for Identification of Primary Benign and Malignant Lung Lesions

作者：X B Liu, Nan Meng, Yihang Zhou, Fangfang Fu, Jianmin Yuan, Zhe Wang, Yang Yang, Zhongyan Xiong, Chao Zou, Meiyun Wang · 发表于：Journal of Magnetic Resonance Imaging · 年份：2024 · DOI：10.1002/jmri.29438 · 被引用次数：5 · 研究领域：MRI in cancer diagnosis、Lung Cancer Diagnosis and Treatment、Radiomics and Machine Learning in Medical Imaging

Background Restriction spectrum imaging (RSI), as an advanced quantitative diffusion‐weighted magnetic resonance imaging technique, has the potential to distinguish primary benign and malignant lung lesions. Objective To explore how well the tri‐compartmental RSI performs in distinguishing primary benign from malignant lung lesions compared with diffusion‐weighted imaging (DWI), and to further explore whether positron emission tomography/magnetic resonance imaging (PET/MRI) can improve diagnostic efficacy. Study Type Prospective. Population 137 patients, including 108 malignant and 29 benign lesions (85 males, 52 females; average age = 60.0 ± 10.0 years). Field Strength/Sequence T2WI, T1WI, multi‐ b value DWI, MR‐based attenuation correction, and PET imaging on a 3.0 T whole‐body PET/MR system. Assessment The apparent diffusion coefficient (ADC), RSI‐derived parameters (restricted diffusion , hindered diffusion , and free diffusion ) and the maximum standardized uptake value (SUVmax) were calculated and analyzed for diagnostic efficacy individually or in combination. Statistical Tests Student's t ‐test, Mann–Whitney U test, receiver operating characteristic (ROC) curves, Delong test, Spearman's correlation analysis. P < 0.05 was considered statistically significant. Results The , SUVmax were significantly higher, and , ADC were significantly lower in the malignant group [0.717 ± 0.131, 9.125 (5.753, 13.058), 0.194 ± 0.099, 1.240 (0.972, 1.407)] compared to the benign group...