Epilepsy alters brain networks in patients with insular glioma

作者：Qifeng He, Zuocheng Yang, Bowen Xue, Xinyu Song, Chuanhao Zhang, Chuandong Yin, Zhenye Li, Zhenghai Deng, Shengjun Sun, Hui Qiao, Jian Xie, Z. L. Hou · 发表于：CNS Neuroscience & Therapeutics · 年份：2024 · DOI：10.1111/cns.14805 · 被引用次数：5 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、EEG and Brain-Computer Interfaces

AIMS: We intend to elucidate the alterations of cerebral networks in patients with insular glioma-related epilepsy (GRE) based on resting-state functional magnetic resonance images. METHODS: We collected 62 insular glioma patients, who were subsequently categorized into glioma-related epilepsy (GRE) and glioma with no epilepsy (GnE) groups, and recruited 16 healthy individuals matched to the patient's age and gender to form the healthy control (HC) group. Graph theoretical analysis was applied to reveal differences in sensorimotor, default mode, visual, and executive networks among different subgroups. RESULTS: No significant alterations in functional connectivity were found in either hemisphere insular glioma. Using graph theoretical analysis, differences were found in visual, sensorimotor, and default mode networks (p < 0.05). When the glioma located in the left hemisphere, the degree centrality was reduced in the GE group compared to the GnE group. When the glioma located in the right insula, the degree centrality, nodal efficiency, nodal local efficiency, and nodal clustering coefficient of the GE group were lower than those of the GnE group. CONCLUSION: The impact of insular glioma itself and GRE on the brain network is widespread. The networks altered by insular GRE differ depending on the hemisphere location. GRE reduces the nodal properties of brain networks than that in insular glioma.