Coagulation abnormalities associated with CAR ‐T‐cell therapy in haematological malignancies: A review

作者：X Peng, Xialin Zhang, Meiling Zhao, Doudou Chang, Linhua Yang, Heng Mei, Ruijuan Zhang · 发表于：British Journal of Haematology · 年份：2024 · DOI：10.1111/bjh.19583 · 被引用次数：14 · 研究领域：CAR-T cell therapy research、Nanowire Synthesis and Applications

Chimeric antigen receptor (CAR)-T-cell therapy has demonstrated considerable efficacy and safety in the treatment of patients with relapsed/refractory haematological malignancies. Owing to significant advances, CAR-T-cell therapeutic modality has undergone substantial shifts in its clinical application. Coagulation abnormalities, which are prevalent complications in CAR-T-cell therapy, can range in severity from simple abnormalities in coagulation parameters to serious haemorrhage or disseminated intravascular coagulation associated with life-threatening multiorgan dysfunction. Nonetheless, there is a lack of a comprehensive overview concerning the coagulation abnormalities associated with CAR-T-cell therapy. With an aim to attract heightened clinical focus and to enhance the safety of CAR-T-cell therapy, this review presents the characteristics of the coagulation abnormalities associated with CAR-T-cell therapy, including clinical manifestations, coagulation parameters, pathogenesis, risk factors and their influence on treatment efficacy in patients receiving CAR-T-cell infusion. Due to limited data, these conclusions may undergo changes as more experience accumulates.