Physical frailty, genetic predisposition, and the risks of severe non‐alcoholic fatty liver disease and cirrhosis: a cohort study

作者：Honghao Yang, Fengrong Ou, Qing Chang, Jinguo Jiang, Yashu Liu, Chao Ji, Liangkai Chen, Yang Xia, Yuhong Zhao · 发表于：Journal of Cachexia Sarcopenia and Muscle · 年份：2024 · DOI：10.1002/jcsm.13506 · 被引用次数：10 · 研究领域：Frailty in Older Adults、Nutrition and Health in Aging、Liver Disease Diagnosis and Treatment

BACKGROUND: Frailty, defined as a phenotype of decreased physiological reserves and diminished ability to respond to stressors, has been linked to the development of chronic diseases. Epidemiological evidence connecting frailty to non-alcoholic fatty liver disease (NAFLD) and cirrhosis risks remain sparse. We aimed to assess the longitudinal associations of frailty with the risks of severe NAFLD and cirrhosis in middle-aged to older adults and further explore the modification role of genetic risk on these associations. METHODS: This study included a total of 398 386 participants from the UK Biobank. Incident cases of severe NAFLD and cirrhosis were ascertained through linked hospital records and death registries. Frailty status was assessed by a modified version of the frailty phenotype, encompassing five key components: weight loss, tiredness, physical activity, gait speed, and grip strength. Participants were classified as pre-frailty if they met one or two of these criteria, and as frailty if they met three or more. Genetic predisposition to NAFLD and cirrhosis was estimated by genetic risk score (GRS) and further categorized into high, intermediate, and low genetic risk levels according to tertiles of GRSs. Cox proportional hazards regression model was employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for their associations. RESULTS: The mean (standard deviation) age of the study population was 56.6 (8.03) years. 214 408 (53.8%) of the partic...