Inhaled heparin: Past, present, and future

作者：Zhewei Liu, Yuqing Ye, Ying Ma, Binjie Hu, Jesse Zhu · 发表于：Drug Discovery Today · 年份：2024 · DOI：10.1016/j.drudis.2024.104065 · 被引用次数：7 · 研究领域：Inhalation and Respiratory Drug Delivery、Heparin-Induced Thrombocytopenia and Thrombosis、Venous Thromboembolism Diagnosis and Management

While heparin has traditionally served as a key anticoagulant in clinical practice for nearly a century, recent years have witnessed a growing interest in its role as a potent antiinflammatory and antiviral agent, as well as an anticancer agent. To address challenges with injection-based delivery, exploring patient-friendly routes such as oral and pulmonary delivery is crucial. This review specifically highlights the multiple therapeutic benefits of inhaled heparin. In summary, this review serves as a valuable source of information, providing deep insights into the diverse therapeutic advantages of inhaled heparin and its potential applications within clinical contexts.