Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial

作者：Xiaoxin Zhou, Xiaoqian Lin, Jing Yu, Yi Yang, Hira Muzammel, Said Amissi, Valérie B. Schini‐Kerth, Xun Lei, Pedro A. José, Jian Yang, Dan Shi · 发表于：Nutrition Journal · 年份：2024 · DOI：10.1186/s12937-024-00967-9 · 被引用次数：24 · 研究领域：Dietary Effects on Health、Enhanced Recovery After Surgery、Nutritional Studies and Diet

Abstract Background Time-restricted eating (TRE), a popular form of intermittent fasting, has shown benefits for improving metabolic diseases and cardiometabolic health. However, the effect of TRE in the regulation of blood pressure in primary hypertension remains unclear. Methods A 6-week randomized controlled trial was conducted, in which a total of 74 stage 1 primary hypertensive patients without high-risk were randomly assigned to Dietary Approaches to Stop Hypertension (DASH) group ( n = 37) or DASH + TRE group ( n = 37). Participants in the DASH + TRE group were instructed to consume their food within an 8-h window. Scientific research platform in We Chat application was used to track participants. The primary outcome was blood pressure. The secondary outcomes included body composition, cardiometabolic risk factors, inflammation-related parameters, urinary Na + excretion, other clinical variables and safety outcomes. Results The reduction of systolic blood pressure and diastolic blood pressure were 5.595 ± 4.072 and 5.351 ± 5.643 mm Hg in the DASH group and 8.459 ± 4.260 and 9.459 ± 4.375 mm Hg in the DASH + TRE group. DASH + TRE group improved blood pressure diurnal rhythm. Subjects in DASH + TRE group had decreased extracellular water and increased urinary Na + excretion. Furthermore, the decrease in blood pressure was associated with a reduction of extracellular water or increase in urinary Na + excretion. In addition, safety outcomes such as nighttime hunger were al...