Tracing the possible evolutionary trends of Morganella morganii : insights from molecular epidemiology and phylogenetic analysis

作者：Jiawei Chen, Yun Wu, Ge Zhang, Wei Kang, Tong Wang, Jin Li, Menglan Zhou, Li Zhang, Yong Liu, Xuesong Xu, Xinmiao Jia, Yingchun Xu, Yali Liu · 发表于：mSystems · 年份：2024 · DOI：10.1128/msystems.00306-24 · 被引用次数：18 · 研究领域：Antibiotic Resistance in Bacteria、Antimicrobial Resistance in Staphylococcus、Pneumonia and Respiratory Infections

ABSTRACT Morganella morganii , encompassing two subspecies, subsp. morganii and subsp. sibonii , is a common opportunistic pathogen, notable for intrinsic resistance to multiple antimicrobial agents. Despite its clinical significance, research into the potential evolutionary dynamics of M. morganii remains limited. This study involved the analysis of genome sequences from 431 M . morganii isolates, comprising 206 isolates that cause host infections, obtained from this study and 225 from the NCBI genome data sets. A diverse array of antimicrobial resistance genes (ARGs) was identified in M. morganii isolates, including mcr-1 , tet (X4), tmexCD-toprJ , and various carbapenemase genes. In addition, a novel bla KPC-2 -bearing plasmid with demonstrated conjugative capability was discovered in M. morganii . The majority of virulence-related genes (VRGs), except for the hlyCABD gene cluster, were found in almost all M. morganii . Three novel genospecies of M. morganii were identified, designated as M. chanii , M. variant1 , and M. variant2 . Compared to M. sibonii , M. chanii genospecies possessed a greater number of flagellar-related genes, typically located within mobile genetic elements (MGEs), suggesting potential for better environmental adaptability. Phylogenetic analysis further disclosed that M. morganii was divided into 12 sequence clusters (SCs). Particularly, SC9 harbored an elevated abundance of ARGs and VRGs, mainly toxin-related genes, and was associated with a higher ...