Chiral α-Aminophosphonates as Ligands in Copper-Catalyzed Asymmetric Oxidative Coupling of 2-Naphthols

作者：Qian-Ming Zuo, Ming‐Ying Wu, Li‐Biao Han, Shang‐Dong Yang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c01582 · 被引用次数：15 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Asymmetric Synthesis and Catalysis、Catalytic C–H Functionalization Methods

Chiral α-aminophosphonates with adjacent carbon and phosphonate stereogenic centers have been employed as ligands in the copper-catalyzed oxidative coupling of 2-naphthols, resulting in the production of chiral BINOLs in favorable yields and moderate to good enantiomeric excess. This represents the first application of chiral P-based ligands to enable such a transformation. The synthesis of these chiral α-aminophosphonate ligands offers a significant advantage over approaches that typically necessitate elaborate synthetic processes for chiral ligand production.