Impaired embryo development potential associated with thyroid autoimmunity in euthyroid infertile women with diminished ovarian reserve

作者：Yongjie Zhang, Yuchao Zhang, Zhuolun Su, Bingnan Ren, Shuang Yu, Wenjing Li, Ninghua Xu, Hua Lou · 发表于：Frontiers in Endocrinology · 年份：2024 · DOI：10.3389/fendo.2024.1376179 · 被引用次数：4 · 研究领域：Thyroid Disorders and Treatments、Ovarian function and disorders、Sperm and Testicular Function

Purpose The aim of this study was to evaluate the associations of thyroid autoimmunity (TAI) with the number of oocytes retrieved (NOR), fertilization rate (FR), and embryo quality (EQ) in euthyroid women with infertility and diminished ovarian reserve (DOR). Methods This retrospective cohort study involved 1,172 euthyroid women aged 20–40 years with infertility and DOR who underwent an oocyte retrieval cycle. TAI was diagnosed in the presence of serum thyroperoxidase antibody (TPOAb) concentrations higher than 34 IU/ml and/or serum thyroglobulin antibody (TgAb) concentrations exceeding 115.0 IU/ml. Among these women, 147 patients with TAI were classified as the TAI-positive group, while 1,025 patients without TAI were classified as the TAI-negative group. Using generalized linear models (GLMs) adjusted for confounding factors, we evaluated the associations of TAI and the serum TPOAb and TgAb concentrations and NOR, FR, and EQ in this study’s subjects. The TPOAb and TGAb values were subjected to log10 transformation to reduce skewness. Logistic regression models were used to estimate the effects of TPOAb and TgAb concentrations on the probabilities of achieving a high NOR (≥7) and high FR (>60%). Results For the whole study population, women with TAI had a significantly lower NOR and poorer EQ than women without TAI ( P < 0.001 for both). Interestingly, in the TSH ≤2.5 subgroup, the TAI-positive group also had a significantly lower NOR and poorer EQ than the TAI...