The predictors to self-reported and performance-based physical function in knee osteoarthritis patients: a cross-sectional study

作者：Qianwen Wang, Gene Chi Wai Man, Ben Chi-yin Choi, Y. T. Au Yeung, Jihong Qiu, Xiaomin Lu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung · 发表于：Frontiers in Cell and Developmental Biology · 年份：2024 · DOI：10.3389/fcell.2024.1406830 · 被引用次数：14 · 研究领域：Osteoarthritis Treatment and Mechanisms、Total Knee Arthroplasty Outcomes、Knee injuries and reconstruction techniques

Background Osteoarthritis (OA) knee patients have limited ability in physical function, or difficulties with physical tasks and activities may develop disability. This study aimed to observe the predictors of self-reported and performance-based physical function in patients with knee OA by analyzing the impacts of demographic, pathological, and muscle impairment factors. Methods 135 knee OA patients participated in this study to complete self-reported questionnaires using Knee Injury and Osteoarthritis Outcome Score (KOOS). When measuring performance-based physical function, a 6-meter gait speed (6MGS) test was measured to evaluate their mobility, and a 5-time Sit-to-Stand test (5STS) was assessed to evaluate their balance. Pain intensity, knee extensor and flexor muscle strength, age, body mass index (BMI), durations of symptoms, and radiographic severity were also collected. Spearman correlation and stepwise multiple linear regression were used to explore the association and predictors in self-reported and performance-based physical function. Results BMI and durations of symptoms did not indicate any significant correlation with either self-reported or performance-based physical function. Age is significantly negatively associated with 6MGS ( r 2 = −0.383, p < 0.01), while knee extensor muscle strength has a moderate correlation with 5STS ( r 2 = −0.528, p < 0.01). In the stepwise multiple linear regression models, pain intensity (β = 0.712, p < 0.001),...