Toward Sub-100 ps TOF-PET Systems Employing the FastIC ASIC With Analog SiPMs

作者：A. Mariscal-Castilla, S. Gomez Fernandez, R. Manera Escalero, J. M. Fernandez-tenllado Arribas, J. Mauricio, N. Kratochwil, J. Alozy, Markus Piller, S. Portero, A. Sanuy, D. Guberman, J. Silva, E. Auffray, R. Ballabriga, Gerard Ariño‐Estrada, M. Campbell, D. Gascón · 发表于：IEEE Transactions on Radiation and Plasma Medical Sciences · 年份：2024 · DOI：10.1109/trpms.2024.3414578 · 被引用次数：24 · 研究领域：Radiation Detection and Scintillator Technologies、Medical Imaging Techniques and Applications、Semiconductor materials and devices

Time of Flight positron emission tomography (TOF-PET) scanners demand electronics that are power-efficient, low-noise, cost-effective, and possess a large bandwidth. Recent developments have demonstrated sub-100 ps time resolution with elevated power consumption per channel, rendering this unfeasible to build a scanner. In this work, we evaluate the performance for the TOF-PET of the FastIC front-end using different scintillators and silicon photomultipliers (SiPMs). FastIC is an eight-channel application specific integrated circuit developed in CMOS 65 nm capable of measuring the energy and the arrival time of a detected pulse with 12 mW per channel. Using Hamamatsu SiPMs (S13360-3050PE) coupled to LSO:Ce:0.2%Ca crystals of$2\times 2\times $3 mm3and LYSO:Ce:0.2%Ca of$3.13\times 3.13\times $20 mm3, we measured a coincidence time resolution (CTR) of ($95~\pm ~3$) and$156~\pm ~4$) ps full width half maximum (FWHM), respectively. With Fondazione Bruno Kessler NUV-HD LF2 M0 SiPMs coupled to the same crystals, we obtained a CTR of ($76~\pm ~2$) and ($127~\pm ~3$) ps FWHM. We employed FastIC with a TlCl pure Cherenkov emitter, demonstrating time resolutions comparable to those achieved with the high-power-consuming electronics. These findings shows that the FastIC represents a cost-effective alternative that can significantly enhance the time resolution of the current TOF-PET systems while maintaining low power consumption.