CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity

作者：Yu Ye, Penghui Jia, Jianxin Miao, Yi‐Cheng Wang, Zibo Li, Yuxin Lin, Miao He, Shurui Liu, Birong Zheng, Junyu Wu, Ji‐An Pan, Chunmei Li, Panpan Hou, Deyin Guo · 发表于：Autophagy · 年份：2024 · DOI：10.1080/15548627.2024.2367183 · 被引用次数：8 · 研究领域：Autophagy in Disease and Therapy、Endoplasmic Reticulum Stress and Disease、Ubiquitin and proteasome pathways

: AD: Alzheimer disease; ALS: amyotrophic lateral sclerosis; ATG5: autophagy related 5; BODIPY: boron-dipyrromethene; CASP3: caspase 3; CCDC50: coiled-coil domain containing 50; CCT2: chaperonin containing TCP1 subunit 2; CHX: cycloheximide; CQ: chloroquine; CRISPR: clustered regulatory interspaced short palindromic repeat; Cas9: CRISPR-associated system 9; DAPI: 4',6-diamidino-2-phenylindole; FK2: Anti-ubiquitinylated proteins antibody, clone FK2; FUS: FUS RNA binding protein; GFP: green fluorescent protein; HD: Huntington disease; HTT: huntingtin; KEGG: Kyoto Encyclopedia of Genes and Genomes; LDS: LIR-docking site; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPT/tau: microtubule associated protein tau; MIU: motif interacting with ubiquitin; NBR1: NBR1, autophagy cargo receptor; OPTN: optineurin; PD: Parkinson disease; PI: propidium iodide; ROS: reactive oxygen species; SOD1: superoxide dismutase 1; SQSTM1/p62: sequestosome 1; TAX1BP1: Tax1 binding protein 1; Ub: ubiquitin; UDS: UIM-docking site; UIM: ubiquitin interacting motif; UPS: ubiquitin-proteasome system.