A universal oral microbiome‐based signature for periodontitis

作者：Mingyan Geng, Min Li, Yun Li, Jiaying Zhu, Chuqing Sun, Yan Wang, Wei‐Hua Chen · 发表于：iMeta · 年份：2024 · DOI：10.1002/imt2.212 · 被引用次数：11 · 研究领域：Oral microbiology and periodontitis research、Oral Health Pathology and Treatment、Streptococcal Infections and Treatments

We analyzed eight oral microbiota shotgun metagenomic sequencing cohorts from five countries and three continents, identifying 54 species biomarkers and 26 metabolic biomarkers consistently altered in health and disease states across three or more cohorts. Additionally, machine learning models based on taxonomic profiles achieved high accuracy in distinguishing periodontitis patients from controls (internal and external areas under the receiver operating characteristic curves of 0.86 and 0.85, respectively). These results support metagenome-based diagnosis of periodontitis and provide a foundation for further research and effective treatment strategies.