Assessment of Anti-arthritis Efficacy of Moringa oleifera: In-silico Molecular Docking

作者：Atul Kumar Pandey, Jitender K Malik, Gyan Singh, Vinay Siroliya · 发表于：Middle East Research Journal of Pharmaceutical Sciences · 年份：2024 · DOI：10.36348/merjps.2024.v04i03.002 · 被引用次数：2 · 研究领域：Moringa oleifera research and applications、Diverse Scientific Research Studies、Drug-Induced Hepatotoxicity and Protection

Background: The severity of rheumatoid arthritis (RA), a chronic, inflammatory, and systemic autoimmune disease, on a patient's joints varies. Age, gender, genetics, and environmental exposure (tobacco use, exposure to air pollution, and occupational exposure) are risk factors. If left untreated, Felty syndrome can develop into a variety of consequences, including rheumatoid vasculitis, persistent joint damage needing arthroplasty, and Felty syndrome necessitating splenectomy. The objectives of treatment for RA are to alleviate discomfort and prevent/slow additional damage because there is no known cure. Munga, also known as Moringa oleifera Lam., is one of the most significant plants grown extensively in India. This plant, Moringa oleifera Lam, is used extensively as a dietary supplement and has valuable pharmacological properties including anti-asthmatic, anti-diabetic, hepatoprotective, anti-inflammatory, anti-cancer, antimicrobial, anti-oxidant, cardiovascular, anti-ulcer, CNS activity, anti-allergic, wound healing, analgesic, and antipyretic action. This plant has great therapeutic properties in every area. It is a good source of milk protein, vitamin A, and vitamin C. Alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil, and lipids are only a few examples of the several active phytoconstituents that are present. Aim and Objective: The goal of the current study was to evaluate M. oleifera leaf anti-arthritic efficacy. Method: In -sil...