Chronic intermittent hypoxia facilitates the development of angiotensin II-induced abdominal aortic aneurysm in male mice

作者：Neekun Sharma, Abdelnaby Khalyfa, Dunpeng Cai, Mariana Morales‐Quinones, Rogério N. Soares, Yusuke Higashi, Shi‐You Chen, David Gozal, Jaume Padilla, Camila Manrique‐Acevedo, Bysani Chandrasekar, Luis A. Martinez‐Lemus · 发表于：Journal of Applied Physiology · 年份：2024 · DOI：10.1152/japplphysiol.00842.2023 · 被引用次数：11 · 研究领域：Aortic aneurysm repair treatments、Aortic Disease and Treatment Approaches、Vascular anomalies and interventions

IH facilitates Ang II-induced abdominal aortic diameter expansion and AAA development in C57BL/6J male mice. IH upregulates the expression of specific MMPs such as MMP8, MMP12, and ADAM17. IH directly suppresses RECK expression and increases MMPs activity in SMCs. Human AAA tissues exhibit a downregulation of RECK and an upregulation of ADAM17 and MMPs.