Elevation of cardiac enzymes and B-type natriuretic peptides following venous recanalization and stenting in chronic venous obstruction

作者：Yan Yan, Mohammad E. Barbati, Efthymios D. Avgerinos, Suat Doğancı, Michael Lichtenberg, Houman Jalaie · 发表于：Phlebology The Journal of Venous Disease · 年份：2024 · DOI：10.1177/02683555241261321 · 被引用次数：1 · 研究领域：Diagnosis and Treatment of Venous Diseases、Atrial Fibrillation Management and Outcomes、Heart Failure Treatment and Management

Background B-type natriuretic peptides (BNP) and cardiac enzymes are both recognized biomarkers of heart health. Many studies have reported that using these indicators can assess cardiac condition and predict prognosis of patients undergoing surgery. Currently little is known on the effect of increased cardiac input after venous recanalization on cardiac physiology in patients with chronic venous obstruction (CVO). Objectives The aim of this study was to explore the effect of iliocaval recanalization and stenting on cardiac biomarkers in patients with CVO. Methods This was a prospective study involving 60 patients in a single unit. Blood tests were collected 1 day before and 1 day after venous intervention. Three groups as group 1: patients with iliofemoral post-thrombotic syndrome (PTS) but without involvement of inferior vena cava (IVC) ( n = 33); group 2: patients with iliofemoral PTS and involvement of IVC ( n = 19) and group 3: patients with non-thrombotic vein lesion (NIVL) ( n = 8) were compared based on cardiac biomarker levels. Results Median concentration of post-operative BNP (259.60 pg/mL) was greater than preoperative levels (49.80 pg/mL) [interquartile range (IQR), 147.15/414.68 versus 29.85/82.88; p < 0.001]. The levels of CK-MB [preop: 3 U/l (IQR, 1.40/11.00) versus postop: 14 U/l (IQR, 12/17), p < 0.001] and troponin T [preop: 3.00 pg/mL (IQR, 3.00/5.25) versus postop: level of 6 pg/mL (IQR, 3.00/9.50), p < 0.001]. Post-procedure increases in cardiac...