Ecofriendly Protocol for ipso-Bromination of Arylboronic Acids

作者：Yiqin Zhou, Kornkamon Akkarasereenon, Lifang Liu, Ran Lin, Liyan Song, Rongbiao Tong · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c01570 · 被引用次数：6 · 研究领域：Chemical Synthesis and Reactions、Oxidative Organic Chemistry Reactions、Catalytic Cross-Coupling Reactions

We report a novel and environmentally friendly method for the ipso -bromination of arylboronic acids by exploiting the oxone/KBr system. We discovered that CuBr can catalyze the reaction and increase the yield from 63 to 97%. We believe that CuBr might catalyze the in situ generation of HOBr from oxone/KBr. The mild reaction condition permits tolerance of a diverse array of functional groups with exclusive regio- and chemoselectivity and allows low-cost large-scale reaction without explosion risk.