Efficacy and safety of Xiangsha liujunzi decoction for functional dyspepsia: a systematic review and meta-analysis

作者：Longhua Wang, Xia Ding, Xinning Yao, Ping Li, Fuwen Zhang, Fenglei Wang, Li Bai, Jing Li · 发表于：Frontiers in Pharmacology · 年份：2024 · DOI：10.3389/fphar.2024.1356899 · 被引用次数：6 · 研究领域：Gastrointestinal motility and disorders、Helicobacter pylori-related gastroenterology studies、Traditional Chinese Medicine Studies

Background Functional dyspepsia is a highly prevalent digestive disorder. The limited effectiveness of current pharmaceutical interventions necessitates the exploration of alternative therapeutic options for functional dyspepsia. Xiangsha liujunzi decoction, a well-known traditional Chinese medicine formulation, has been widely employed in the treatment of functional dyspepsia in China. Nevertheless, the effectiveness of Xiangsha liujunzi decoction in the treatment of functional dyspepsia remains uncertain. Objective To examine the effectiveness and safety of Xiangsha liujunzi decoction for treating functional dyspepsia. Methods We retrieved seven databases containing randomized controlled trials on functional dyspepsia published up until 31 July 2023. The quality of these studies was evaluated using the Cochrane Risk of Bias assessment tool. The analysis of data was performed using the software RevMan 5.4. The total clinical effectiveness rate was evaluated as the primary outcome. In addition, gastric emptying rate, symptom score and safety evaluation were evaluated as the secondary outcomes. Results The meta-analysis included 23 studies, involving 2,101 individuals. Xiangsha liujunzi decoction demonstrated a significantly higher clinical effectiveness rate compared to the control group (RR 1.27; 95% CI 1.21, 1.33; p < 0.00001). Moreover, it exhibited superior gastric emptying rate and symptom score improvement compared to the control group. Nevertheless, no remarkabl...