Aspects of Area Deprivation Index in Relation to Hippocampal Volume Among Children

作者：Benson S. Ku, Katrina Aberizk, Cope Feurer, Qingyue E. Yuan, Benjamin G. Druss, Dilip V. Jeste, Elaine F. Walker · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.16484 · 被引用次数：34 · 研究领域：Dementia and Cognitive Impairment Research、Stress Responses and Cortisol、Functional Brain Connectivity Studies

Importance: Area deprivation index (ADI) has been shown to be associated with reduced hippocampal volume (HV) among youths. The social environment may interact with the association between ADI and HV. Objective: To investigate which aspects of ADI are uniquely associated with bilateral HV and whether school and family environments have moderating interactions in associations between ADI and HV. Design, Setting, and Participants: This cross-sectional study used data from the Adolescent Brain and Cognitive Development (ABCD) study. Participants aged 9 and 10 years were recruited from 21 sites in the US between September 2016 and August 2018. Data analysis was performed between March 2023 and April 2024. Exposures: ADI aspects were derived from participant primary home addresses provided by parents or guardians. Main Outcomes and Measures: HV was automatically segmented from structural brain images ascertained from magnetic resonance imaging. Multiple generalized linear mixed modeling tested associations between 9 indices of ADI and bilateral HV, with family groups and recruitment sites as random effects. After stepwise backward selection, models were adjusted for individual-level covariates, including age, sex, race and ethnicity, parental education, household income, and estimated intracranial volume. Results: This study included 10 114 participants aged 9 and 10 years (median [IQR] age, 9.92 [9.33-10.48] years; 5294 male [52.3%]; 200 Asian [2.0%], 1411 Black [14.0%], and 6655...