De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

作者：Min Jiang, Guohui Zhang, Yuan Yu, Yuhong Zhao, Jun Liu, Qin Zeng, Meng-Yue Feng, Fei Ye, Dongsheng Xiong, Li Wang, Yanan Zhang, Ling Yu, Jiajing Wei, Libing He, Weiwei Zhi, Xin-Rong Du, Ning-Jing Li, Changli Han, Heqiu Yan, Zhuo-Ting Zhou, Yang‐Bao Miao, Wen Wang, Weixin Liu · 发表于：Journal of Nanobiotechnology · 年份：2024 · DOI：10.1186/s12951-024-02602-5 · 被引用次数：10 · 研究领域：Reproductive Biology and Fertility、Sperm and Testicular Function、Bone Tissue Engineering Materials

The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovarian tissue cryopreservation and transplantation (OTC-T), including the risk of tissue damage and dysfunction. Consequently, there has been a compelling exploration into the realm of nanoregulators to refine and enhance these procedures. This review embarks on a meticulous examination of the intricate anatomical structure of the ovary and its microenvironment, thereby establishing a robust groundwork for the development of nanomodulators. It systematically categorizes nanoregulators and delves deeply into their functions and mechanisms, meticulously tailored for optimizing ovarian tissue cryopreservation and transplantation. Furthermore, the review imparts valuable insights into the practical applications and obstacles encountered in clinical settings associated with OTC-T. Moreover, the review advocates for the utilization of microbially derived nanomodulators as a potent therapeutic intervention in ovarian tissue cryopreservation. The progression of these approaches holds the promise of seamlessly integrating nanoregulators into OTC-T practices, thereby heralding a new era of expansive applications and auspicious prospects in this pivotal domain.