Metal–Organic Framework-Based Surface-Enhanced Raman Scattering Sensing Platform for Trace Malondialdehyde Detection in Tears

作者：Jinming Li, Haozhe Yu, Jianming Zhao, Xuezhi Qiao, Xiangyu Chen, Zhaoxiang Lu, Qiaoyu Li, Haimiao Lin, Wenyu Wu, Weizhen Zeng, Zhou Yang, Yun Feng · 发表于：Nano Letters · 年份：2024 · DOI：10.1021/acs.nanolett.4c01978 · 被引用次数：33 · 研究领域：Advanced Nanomaterials in Catalysis、Advanced Chemical Sensor Technologies、Biosensors and Analytical Detection

Disease biomarkers in tears are crucial for clinical diagnosis and health monitoring. However, the limited volume of tear samples, low concentration of tear biomarkers, and complex tear composition present challenges for precise testing. We introduce a spot-on testing platform of metal–organic framework (MOF)-based surface-enhanced Raman scattering (SERS) capillary column, which is capable of target molecules selective separation and enrichment for tear biomarkers in situ detection. It consists of Au nanostars for effective SERS signal and a porous MOF shell for separating impurities through molecular sieving effect. This platform allows for simultaneous collection and detection of tear, capturing the disease biomarker malondialdehyde in tears with a 9.38 × 10 –9 mol/L limit of detection. Moreover, we designed a hand-held device based on this tubular SERS sensor, successfully diagnosing patients with dry eye disease. This functional capillary column enables noninvasive and rapid diagnosis of biomarkers in biofluids, providing potential for disease diagnosis and healthcare monitoring.