Development and validation of a nomogram for suicide attempts in patients with first-episode drug-naïve major depressive disorder

作者：Junjun Liu, Ruixiang Tong, Zhaomin Lu, Zhiye Wang, Yangchun Wang, Yang Liu, Hsinsung Yuan, Fengnan Jia, Xiaobin Zhang, Xiaobin Zhang, Zhe Li, Xiangdong Du, Xiangyang Zhang, Xiangyang Zhang · 发表于：Frontiers in Psychiatry · 年份：2024 · DOI：10.3389/fpsyt.2024.1398733 · 被引用次数：4 · 研究领域：Suicide and Self-Harm Studies、Treatment of Major Depression、Tryptophan and brain disorders

Objective: The risk of suicide can be decreased by accurately identifying high-risk suicide groups and implementing the right interventions. The aim of this study was to develop a nomogram for suicide attempts (SA) in patients with first-episode drug-naïve (FEDN) major depressive disorder (MDD). Methods: This study undertook a cross-sectional analysis of 1,718 patients diagnosed with FEDN MDD, providing comprehensive clinical data from September 2016 to December 2018. Data on anthropometric and sociodemographic factors were gathered, and the severity of depression and anxiety was evaluated using the 17-item Hamilton Depression Scale (HAMD-17) and the Hamilton Anxiety Scale (HAMA), respectively. Additionally, thyroid hormone levels, lipid profile parameters, and fasting blood glucose (FBG) were measured. Suicide attempt (SA) history was verified based on an amalgamation of medical records, patient interviews, and family interviews. Participants were randomly divided into a training group (70%, n = 1,204) and a validation group (30%, n = 514). In the training group, LASSO analysis and multivariate regression were used to identify variables associated with SA. A nomogram was then constructed using the identified risk factors to estimate the likelihood of SA within the training group. To assess the accuracy, the area under the receiver operating characteristic curve (AUC) was utilized, and calibration plots were employed to evaluate calibration. Additionally, decision curve analy...