Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study

作者：Kausik Kumar Ray, Carlos Aguíar, Marcello Arca, Derek Leslie Connolly, Mats A. L. Eriksson, Jean Ferrières, Ulrich Laufs, José M. Mostaza, David Nanchen, A. Bardet, Mathias Lamparter, Richa Chhabra, Jarkko Soronen, Ernst R. Rietzschel, Timo E. Strandberg, Hermann Toplak, Frank L.J. Visseren, Alberico Luigi Catapano, the SANTORINI Study Investigators, Herrmann Toplak, Christian Hengstenberg, Martin Clodi, Bernhard H. Ludvik, Christoph F. Ebenbichler, Gerit-Holger Schernthaner, Ursula Hanusch, Johannes Auer, Andreas Schober, Hannes Franz Alber, Andreas Zirlik, Evelyn Fließer-Görzer, Thomas Maca, Reinhard Sock, Thomas M. Stulnig, Raimund Weitgasser, Alexander Kober, Carmen Gelsinger, Fabian Demeure, Yvan Calozet, Frank J.S. Cools, Tom Sarens, Peter Versyck, Filip Vanstechelman, Luc Capiau, Karl Dujardin, Philippe Vanduynhoven, Alex Heyse, Luc Janssens, Filip De Man, Ivan Elegeert, Raf Roelandt, Philippe Evrard, Rachid Maamar, Philippe van de Borne, Hans J. Vandekerckhove, Eva Decaluwe, Bernard Cosyns, Olivier S Descamps, Denis Pieters, Geert Hollanders, Emmanuel Catez, Axel De Wolf, Ernst Rietzschel, Panagiotis Xaplanteris, Rossen Hildebrandt, Morten Kofod Lindhardt, Helle Klingenberg Iversen, Gunnar Gislason, Anders Nikolai Ørsted Schultz, Jens Due Lomholdt, Hanne Krarup Christensen, Kristian Korsgaard Thomsen, Merete Heitmann, Jens Broennum-Schou, Søren Galatius, Christian Tuxen, Timo E. Strandberg, Sakari Sulosaari, Satu E. Näppi, Kai Nyman, Marta Abraham, Ilkka M Kantola, Sakari Kekki, Kristiina Averson, Janne Hukkanen, Pirkko Korsoff, A. Lagerstedt, Jyrki Taurio, Nelli Valkama, Juha E.K. Hartikainen, Veli-Matti Häggman, Sari Risku, Mikko Syvänne, ROBERT E. PAUL, Harri Hietanen, Arto Y. Strandberg, Jussi Talka, Tommi Aaltokallio, Nicolas Delarche, Maxime Fayard, Serge Cohen, Emile Ferrari, Fahmi Ghanem, Gérard Dassa, Julien Lenestour, Jean-Noël Labèque, Eric Decoulx, Benjamin Caze, Gilles Lemesle, Laurent Delorme, Claire Bouleti, Jeannot Razafy, O. Azzano, Gilles Barone‐Rochette, Jean‐Michel Tartière, Gilles Montalescot, Guillaume Cayla, Jacques Berland, Sébastien Caudmont, Renaud Solanet, Franck Boccara, Jean-Noël Andarelli, G Lévy, Vincent Troussard, Stéphane Mingam, François Poulain, Vincent Probst, Alain Furber, Bertrand Cariou, Grégoire Rangé, Martin Audonnet, Jérôme Clerc, Thierry Lemercier, Jean-Philippe Mouret, Docteur Rachenne, Pierre‐François Lesault, Boutheina Zeghidi, Jean Ferrières, Damien Broucqsault, Christian Duroy, Victor Aboyans, Dominique Stéphan, Ulrich Laufs, Gregor Simonis, Frank Schäper, Ulrike Schatz, Hans-Holger Ebert, Christoph Axthelm, Wolfram Oettler, Matthias Weißbrodt, Eigk Grebe, Ina Wittig, Antje Spens, Jens Taggeselle, Ulrike Spengler, Andreas Hagenow, Axel Schlitt, Frank Menzel, Jörg Langel, Jens Gerth, Alexander Leißring, Dieter Enders, Heiko Stellmach, Ursula Kassner, Werner A Rieker, Claudia Zemmrich, Matthias Claus, Anne Winkelmann, Steffen Behrens, THOMAS VOGTMANN, Ulrich M. Wolf, Oliver Ritter, Michael Rother, Hüseyin İnce, Heinrich Prophet, Behrus Subin, Christina Paitazoglou, Thomas Twisselmann, Joachim Schöfer, Andreas Wilke, Detelin Denchev, Muhammed Gerçek, Uwe Gerbaulet, Stephan Gielen, Andreas Götte, Karl‐Friedrich Appel, Jörg Simon, Katja S. C. Gollisch, Markus Baar, Matthias Stratmann, Nils Dyckmanns, Thomas Wetzel, Bernd Schütz, Axel Schaefer, Afif Haj-Yehia, Ludger Rose, Christian Fechtrup, Katrin Gebauer, Sven Nissen Meyer, Martin Klutmann, Astrid K. Schmidt-Reinwald, Nikos Werner, Rainer Bernd Zotz, Christine Espinola–Klein, Philipp Sebastian Wild, Sabine Genth‐Zotz, Fabian Krämer, Thomas Horacek, Veselin Mitrovic, Wolfgang Jungmair, Jörg Hintze, Stephan Steiner, C Kadel, Jennifer D. Illana Wolf, Josef Lißmann, Michael C Böhm, B Hammer, Karl Bruck, Tim Süselbeck, Holger Killat, Stephan Henrik Schirmer, P. Salbach, Ksenija Stach, Christian Erbel, Grigorios Korosoglou, Oliver Scheuermann, RALPH F. BOSCH, Erwin Blessing, Stefan E. Hardt, Stefan Leggewie, Michael Schmid, Heiko Methe, Harry Hahmann, Norbert Jahnke, Alexander Stadelmann, Michael Jeserich, Johannes‐Peter Haas, Steffen Schnupp, Petra Herrmann, Martin Fassnacht-Capeller, Karl-Heinz Schermaul, Ronald Naumann, Jan Ernstberger, Marlena Retkowska, Stephan Jacob, Frank Hamann, Mahmoud Delonge, Sagy El-Meadawy, Katharina Hellhammer, Katrin Eberhard, Martin Köhrmann, Nadine K. Waessnig, Markus Buresch, K. J. Osterziel, Eva Olesch, Jens Jung, Annika Voigt, Diethard Predel, Jörg-Eike Scholle, Clemens Schiffer, Stefan Lukannek, Ilka Simon-Wagner, Heiner Methfessel, Andree Allers, Hermann Braun, Toralf Schwarz, Heidrun Täschner, Sandra Schulz, Bernadett Brado, Daniel Zandt, Annette Birkenhagen, Cornelia Woitek, G Várnai, WOLFGANG M. HARTUNG, K. Schwabe, Andreas Schreckenberg, Frank Warzok, Nalan Coban, Martin Prohaska, Mustafa Durak, Detlef Bernd Gysan, Markus Zarse, Harilaos Bogossian, Roy Ben-Chur, Thomas A. Walter, Sabine Hansen, Hans-Jürgen Ohler, Alexander Krapivsky, Marcello Arca, Matteo Pirro, Francesco Giorgino, Patrizia Suppressa, Francesco Cipollone, Claudio Ferri, Giovambattista Desideri, Elena Alberghini, Matteo Nicola Dario Di Minno, Ciro Mauro, Roberta Lupoli, A. E. Pípolo, Marco Francesco Lococo, Mauro Feola, Maurizio Averna, Giovanni Licciardello, Rossella Marcucci, Claudio Borghi, Roberto Catalini, Federico Guerra, Riccardo Sarzani, Daniele Nassiacos, Gianluca Calogero Campo, Egidio Imbalzano, Tiziano Angelo Lucchi, Mariano Pellicano, Gianni Casella, Elena Repetti, Michele Antonio Clemente, Massimo Natale, Gaetano Maria De Ferrari, Natale Daniele Brunetti, Giovanni Esposito, Giovanni Fazio, Paolo Calabrò, Luca Dalle Carbonare, Antonia Albertí, Edoardo Mannucci, Agostino Gnasso, Giuseppe Andò, Francesco Paolo Amico, Giuseppina Novo, Massimo Alessandri, Andrea Di Lenarda, Tiziana Sampietro, Stefano Gonnelli, Domenico D’Amario, Claudio Bilato, Livia Pisciotta, Tiziana Montalcini, Paolo Golino, Marino Scherillo, Giuseppe Boriani, Giovanni Luzzi, Ciro Indolfi, Stefano Mazzarino, Antonio Mugnolo, Elio Gorga, Alessandra Fiorentini, Guido Parodi, Raffaele De Caterina, María Lorenza Muiesan, Daniele Andreini, Alessandro Navazio, M Straniti, Maria Del Ben, Francesca Carubbi, Daniela Aschieri, Claudio Fresco, Massimo Grimaldi, José Pablo Werba, Roberto Trevisan, Antonino Nicosia, Donata Angela Mor, Emilio Di Lorenzo, Natale Di Belardino, Angelina Passaro, Anna Solini, Antonio Lanzilli, Vittorio Salvatore, Giuseppe Colonna, Alessandro Lupi, Carlo Di Mario, Luigi Di Lorenzo, Ilaria Jacomelli, Giovanni Paternò, Giuseppe Mandraffino, Giovanni Tortorella, Marta Focardi, Giuseppe DE BLASIO, Cinzia Vespucci, Roberto Cemin, E Ferdenzi, Lucia Filippucci, Liliana Grigore, Lorenzo Maroni, Paolo Midi, Giorgio Sesti, Emilio Di Vincenzo, Francesco Prati, Michele Comito, Alessandro Sciahbasi, Franco Bui, Francesco Grigioni, Gianfranco Tortorici, Vito Sollazzo, Mirza Becirovic, Giuseppe Caramanno, Adriana Branchi, Dario Manfellotto, Fabio Menghini, Nazzareno Galiè, Massimo Puato, Adriana Visonà, Filippo Maria Sarullo, Carmine Vecchione, Raffaele Marfella, Anna Dell'elce, Annamaria Nicolino, Martijn van Eck, Gerard C.M. Linssen, Bas Hamer, Björn E. Groenemeijer, Driek Beelen, Maarten Asselman, Karin Arkenbout, J. T. Drost, Fabrice M A C Martens, C. de Nooijer, Dirk A. A. M. Schellings, Stijntje Zoet-Nugteren, Frank L.J. Visseren, Ismail Aksoy, J. Wouter Jukema, Clara Van Ofwegen-Hanekamp, Jan C. Constandse, Thomas Oosterhof, Pieter A. Dijkmans, Robert M. van Es, Aaf F.M. Kuijper, Arnout Haasdijk, Eric P. Viergever, Jeroen van Etten, Marc van Zee, Walter R. M. Hermans, Matthijs F.L. Meijs, Ka Wai Wu, Ruud van de Wal, Carlos Aguiar, Pedro Monteiro, Jorge Mimoso, João Sequeira Duarte, Fausto José Pinto, Patrício Aguiar, JOÃO PEDRO MARCHETTI FREIXO RAPOSO, Fernando Campos Gomes Pinto, Davide Maurício Carvalho, Pedro VON HAFE, Paulo Jorge Pereira Alves, Richard G. Sheahan, Ross T. Murphy, David Burke, Eugene Patrick McFadden, Robert A. Byrne, Dermot Nolan, José María Mostaza, Carlos H Lahoz, Pedro Chinchurreta, I. Pinal, Manuel Martínez‐Sellés, Beatriz Pérez-Villardón, Luis Garcia Ortiz, Santiago Jesús Camacho Freire, Javier Chimeno García, Abel García del Egido, Antonio Miguel Barragán Acea, M. Bermudez, José Luis Moriñigo Muñóz, Pedro Valdivieso, Carlos Pérez Muñoz, Javier León, Jordi Puntí Sala, Manuel Jesús Romero Jimenez, José Manuel Rubio Campal, Eddie Velásques, Antonio José Fernández Romero, Saul Suarez, Fernando Gómez Peralta, Xavier Pinto Sala, Vanessa Escolar Pérez, Amaia Ibarra Gutiérrez, Olga Quiñones, Carlos Arias Miranda, J. Serra Aracil, Consuelo Olivo, Isabel Belloso, F. Delgado, Victor León Arguero, Juan Pedro Botet Montoya, Domingo Andrés Pascual-Figal, Antonio Gómez Menchero, Mònica Salomó Domènech, Raquel Solanilla Rodríguez, Iris Maria Esteve Ruiz, Antonio Pérez, Reyes Oliva Encabo, Pedro Talavera, Elvira Blanco, Fernando Alfonso Manterola, J. Vega Fernández, Teresa Arrobas, Carlos Escobar, Núria Plana, Luís Manzano, Iluminada García Polo, José Luis Díaz-Díaz, Moisés Rodríguez‐Mañero, Sonia Ruiz, García Díaz, Carlos Guijarro Herraiz, Fernando Civeira Murillo, Francisco Martínez Debén, Leopoldo Pérez de Isla, Juan Diego Mediavilla García, Juan Carlos Pérez Marin, Manuel García De Yébenes Castro, Mónica Marazuela, Rafael Simó, Rafael Ramírez Montesinos, Isabel Pavón de Paz, Cristina Abreu, África García Roy, R. Cañas, Carles Jericó, José Luis Zamorano, Antonia Espinosa Collado, Javier Espiga Alzola, José L. Hernández, Jorge Francisco Gómez Cerezo, Agustín Blanco Echevarría, Antonio García Quintana, Alberto Esteban‐Fernández, Manuel Suárez Tembra, Santiago Jesús Camacho Freire, Mats A. L. Eriksson, Carl-Johan Lindholm, Andrzej Sloma, Anders Gottsäter, Stefano Romeo, Mikael Dellborg, Nils Witt, Neshro Barmano, Peter Hällgren, Staffan Salmonsson, Christos Milonas, David Nanchen, Konstantinos C. Koskinas, Georg Ehret, Isabella Sudano, Christian Eugen Mueller, Michael Egloff, Stefan Bilz, Christophe Alain Wyss, André R. Miserez, Florim Cuculi, Stéphane Bosquet, Gottfried Rudofsky, Michel Romanens, Samir Purnell Mullick, Damien McNally, Anthony Gunstone, John Ryan, Jonathan Garstang, Nick Jacobsen, Andrew Moriarty, Wayne Turner, Terry McCormack, Timothy S. Johnson, Matthew Capehorn, Chris Schramm, Paul Guyler, Deepa Narayanan, Graham C Toms, Paul David Ainsworth, Margaret Ikpoh, Ahmet Fuat, Jon Mark Dickson, Nigel E. Capps, Karthik Viswanathan, Stewart Pattman, Satheesh Balakrishnan-Nair, Angela Gbegbaje, Manish Saxena, Christopher Keast, Duncan Browne, Azhar Zafar, Gregory Y H Lip, PATRICK J. MOORE, Stacey Fisher, Stacey Fisher, Stacey Fisher, Gareth T. Powell, Tamsin Sevenoaks, Tom Hyde, Peter E. Carey, Mike Butler, Cyril Evbuomwan, S Thiagu, Ian S. Schofield, Gordon W. Irvine, Farzan Kamali, Stephanie F. Hughes, John Wakeling, Samir Purnell Mullick, Kausik Kumar Ray, Alberico Luigi Catapano, Carlos Aguiar, Marcello Arca, Derek L Connolly, Mats A. L. Eriksson, Jean Ferrières, Per Rossen Hildebrandt, Ulrich Laufs, José M. Mostaza, David Nanchen, Ernst Rietzschel, Timo E. Strandberg, Hermann Toplak, Frank L.J. Visseren · 发表于：European Journal of Preventive Cardiology · 年份：2024 · DOI：10.1093/eurjpc/zwae199 · 被引用次数：79 · 研究领域：Lipoproteins and Cardiovascular Health、Antiplatelet Therapy and Cardiovascular Diseases、Cardiac Health and Mental Health

AIMS: To assess whether implementation of the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidaemia guidelines observed between 2020 and 2021 improved between 2021 and 2022 in the SANTORINI study. METHODS AND RESULTS: Patients with high or very high cardiovascular (CV) risk were recruited across 14 European countries from March 2020 to February 2021, with 1-year prospective follow-up until May 2022. Lipid-lowering therapy (LLT) and 2019 ESC/EAS risk-based low-density lipoprotein (LDL) cholesterol (LDL-C) goal attainment (defined as <1.4 mmol/L for patients at very high CV risk and <1.8 mmol/L for patients at high CV risk) at 1-year follow-up were compared with baseline. Of 9559 patients enrolled, 9136 (2626 high risk and 6504 very high risk) had any available follow-up data, and 7210 (2033 high risk and 5173 very high risk) had baseline and follow-up LDL-C data. Lipid-lowering therapy was escalated in one-third of patients and unchanged in two-thirds. Monotherapy and combination therapy usage rose from 53.6 and 25.6% to 57.1 and 37.9%, respectively. Mean LDL-C levels decreased from 2.4 to 2.0 mmol/L. Goal attainment improved from 21.2 to 30.9%, largely driven by LLT use among those not on LLT at baseline. Goal attainment was greater with combination therapy compared with monotherapy at follow-up (39.4 vs. 25.5%). CONCLUSION: Lipid-lowering therapy use and achievement of risk-based lipid goals increased over 1-year follow-up particularl...