Predictive Value of Serum Inflammatory Factors and FT3 for Stroke-Associated Pneumonia in Patients With Acute Ischemic Stroke

作者：Xin Li, Xiaomei Xie, Shenju Cheng, Shan Luo, Yancui Zhu, Kun Wu · 发表于：The Neurologist · 年份：2024 · DOI：10.1097/nrl.0000000000000570 · 被引用次数：3 · 研究领域：Pneumonia and Respiratory Infections、Neuroinflammation and Neurodegeneration Mechanisms、Dysphagia Assessment and Management

OBJECTIVE: The ability of serum inflammatory factors and free triiodothyronine (FT 3 ) in predicting the occurrence of stroke-associated pneumonia (SAP) in patients with acute ischemic stroke (AIS) was assessed in this study. METHODS: A retrospective analysis was conducted on 285 consecutive patients with AIS initially diagnosed and admitted to our hospital from January to December 2022. Patients were categorized into SAP and non-SAP groups based on the presence of SAP. Both groups were compared in terms of baseline characteristics, including National Institute of Health Stroke Scale (NIHSS) score, SAP risk assessment (A 2 DS 2 ), TOAST classification. Independent risk factors for SAP were identified using multivariate logistic regression analysis, and the predictive value of inflammatory markers was evaluated through ROC curves. RESULTS: Among 285 patients with AIS, 40 (14.03%) were found to have developed SAP. Higher NIHSS and A 2 DS 2 scores, elevated serum IL-1β, IL-8, and IL-33 levels, increased age, atrial fibrillation, swallowing difficulties, and a higher proportion of patients with low FT 3 levels were observed in the SAP group compared with the non-SAP group (all P <0.05). Significant risk factors for SAP in patients with AIS were identified through multivariate logistic regression analysis, including age, swallowing difficulties, NIHSS, A 2 DS 2 , IL-1β, IL-8, IL-33, and FT 3 ( P <0.05). The highest predictive values were observed for A 2 DS 2 , FT 3 , and IL-8 wit...