Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

作者：Natasha I. Edman, Ashish Phal, Rachel L. Redler, Thomas Schlichthaerle, Sanjay Srivatsan, Devon Duron Ehnes, Ali Etemadi, Seong Jin An, Andrew Favor, Zhe Li, Florian Praetorius, Max Gordon, Thomas L. Vincent, Silvia Marchianò, Leslie P. Blakely, Chuwei Lin, Wei Yang, Brian Coventry, Derrick R. Hicks, Longxing Cao, Neville P. Bethel, Piper Heine, Analisa Murray, Stacey Gerben, Lauren Carter, Marcos C. Miranda, Babak Negahdari, Sangwon Lee, Cole Trapnell, Ying Zheng, Charles E. Murry, Devin K. Schweppe, Benjamin Freedman, Lance Stewart, Damian C. Ekiert, Joseph Schlessinger, Jay Shendure, Gira Bhabha, Hannele Ruohola‐Baker, David Baker · 发表于：Cell · 年份：2024 · DOI：10.1016/j.cell.2024.05.025 · 被引用次数：57 · 研究领域：Fibroblast Growth Factor Research、Phagocytosis and Immune Regulation、Tissue Engineering and Regenerative Medicine

release and mitogen-activated protein kinase (MAPK) pathway activation. The high specificity of the designed agonists reveals distinct roles for two FGFR splice variants in driving arterial endothelium and perivascular cell fates during early vascular development. Our designed modular assemblies should be broadly useful for unraveling the complexities of signaling in key developmental transitions and for developing future therapeutic applications.