A mobile device-based game prototype for ADHD: development and preliminary feasibility testing

作者：Jie Luo, Fenghua Li, Yuanzhen Wu, Xuanang Liu, Qingyi Zheng, Yan‐Jie Qi, Huanhuan Huang, Gaoyang Xu, Zhengkui Liu, Fan He, Yi Ling Zheng · 发表于：Translational Psychiatry · 年份：2024 · DOI：10.1038/s41398-024-02964-2 · 被引用次数：15 · 研究领域：Attention Deficit Hyperactivity Disorder、Cognitive Abilities and Testing、Children's Physical and Motor Development

This research aimed to devise and assess a mobile game therapy software for children with Attention-Deficit/Hyperactivity Disorder (ADHD), as well as evaluating its suitability and effectiveness in improving the cognitive ability of typically developing children. The study encompassed 55 children diagnosed with ADHD and 55 neurotypical children. Initial assessments involved ADHD-related scales, computerized tests for information processing, and physiological-psychological evaluations. After a 4-week home-based game intervention, participants underwent re-evaluation using baseline measures and provided feedback on treatment satisfaction. Considering the small proportion of study participants who dropped out, data was analyzed using both the Intention-to-Treat (ITT) analysis and the Per-protocol (PP) analysis. The trial was registered at ClinicalTrials.gov (NCT06181747). In ITT analysis, post-intervention analysis using linear mixed models indicated that the ADHD group improved significantly more than the neurotypical group particularly in Continuous Performance Test (CPT) accuracy (B = -23.92, p < 0.001) and reaction time (B = 86.08, p < 0.01), along with enhancements in anti-saccade (B = -10.65, p < 0.05) and delayed-saccade tasks (B = 0.34, p < 0.05). A reduction in parent-rated SNAP-IV scores was also observed (B = 0.43, p < 0.01). In PP analysis, paired-sample t-tests suggested that the ADHD group had significant changes pre- and post-intervention, in terms of CPT Accuracy...