Dixon MRI-based quantitative parameters of extraocular muscles, intraorbital fat, and lacrimal glands for staging thyroid-associated ophthalmopathy

作者：Xiong‐Ying Pu, Lu Chen, Hao Hu, Qian Wu, Wenhao Jiang, Jinling Lu, Huanhuan Chen, Xiao‐Quan Xu, Fei‐Yun Wu · 发表于：Insights into Imaging · 年份：2024 · DOI：10.1186/s13244-024-01693-w · 被引用次数：13 · 研究领域：Ophthalmology and Eye Disorders、Vestibular and auditory disorders、Thyroid Cancer Diagnosis and Treatment

Abstract Objective To investigate the value of Dixon magnetic resonance imaging (MRI)-based quantitative parameters of extraocular muscles (EOMs), intraorbital fat (IF), and lacrimal glands (LGs) in staging patients with thyroid-associated ophthalmopathy (TAO). Methods Two hundred patients with TAO (211 active and 189 inactive eyes) who underwent Dixon MRI for pretreatment evaluation were retrospectively enrolled and divided into training (169 active and 151 inactive eyes) and validation (42 active and 38 inactive eyes) cohorts. The maximum, mean, and minimum values of the signal intensity ratio (SIR), fat fraction (FF), and water fraction (WF) of EOMs, IF, and LGs were measured and compared between the active and inactive groups in the training cohort. Binary logistic regression analysis, receiver operating characteristic curve analysis, and the Delong test were used for further statistical analyses, as appropriate. Results Compared with inactive TAOs, active TAOs demonstrated significantly greater EOM-SIR max , EOM-SIR mean , EOM-SIR min , IF-SIR max , IF-SIR mean , LG-SIR max , LG-SIR mean , EOM-WF mean , EOM-WF min , IF-WF max , IF-WF mean , and LG-WF mean and lower EOM-FF max , EOM-FF mean , IF-FF mean , IF-FF min , and LG-FF mean values (all p < 0.05). The EOM-SIR mean , LG-SIR mean , and LG-FF mean values were independently associated with active TAO (all p < 0.05). The combination of the EOM-SIR mean , LG-SIR mean , and LG-FF mean values showed better performanc...