Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/− mice

作者：Yan‐Hong Lang, Chengrui Zhong, Lingling Guo, Zhijie Liu, Dinglan Zuo, Xi Chen, Liuyan Ding, Bi‐Jun Huang, Binkui Li, Yunfei Yuan, Yi Niu, Jiliang Qiu, Chao‐Nan Qian · 发表于：iScience · 年份：2024 · DOI：10.1016/j.isci.2024.110205 · 被引用次数：3 · 研究领域：Lipid metabolism and biosynthesis、Cancer, Lipids, and Metabolism、Metabolomics and Mass Spectrometry Studies

Monoacylglycerol acyltransferase-2 (MOGAT2), encodes MOGAT enzyme in the re-synthesis of triacylglycerol and protects from metabolism disorders. While, its precise involvement in colorectal cancer (CRC) progression remains inadequately understood. Our study demonstrated that knockout of Mogat2 in Apc min/+ mice expedited intestinal tumor growth and progression, indicating that Mogat2 plays a tumor-suppressing role in CRC. Mechanically, Mogat2 deletion resulted in a significant alter the gut microbiota, while Fecal Microbiota Transplantation (FMT) experiments demonstrated that the gut microbiota in Mogat2 deleted mice promoted tumor growth. Furthermore, we identified Mogat2 as a functional regulator suppressing CRC cell proliferation and tumor growth by inhibiting the NF-κB signaling pathway in vivo . Collectively, these results provide novel insights into the protective double roles of Mogat2, inhibiting of NF-κB pathway and keeping gut microbiota homeostasis in colorectal cancer, which may help the development of novel cancer treatments for CRC.