Associations between smoking, sex steroid hormones, trouble sleeping, and depression among U.S. adults: a cross-sectional study from NHANES (2013–2016)

作者：Jing Huang, Peiwen Shi, Yuan Zhao, Huinan Zhang, Tian Gao, Xing Wang · 发表于：BMC Public Health · 年份：2024 · DOI：10.1186/s12889-024-19045-0 · 被引用次数：12 · 研究领域：Sleep and related disorders、Smoking Behavior and Cessation、Stress Responses and Cortisol

Abstract Background Dose-response and nonlinear relationships of cigarette exposure with sleep disturbances and depression are warranted, and the potential mechanism of sex hormones in such associations remains unclear. Methods Cigarette exposure, trouble sleeping, and depression were assessed by standard questionnaires, and the levels of cotinine and sex steroid hormones were determined among 9900 adults from the National Health and Nutrition Examination Survey (NHANES). Multiple linear regression, logistic regression, and mediation models were conducted to evaluate the associations between smoking, sex steroid hormones, trouble sleeping, and depression. Results With never smokers as a reference, current smokers had a higher prevalence of trouble sleeping (OR = 1.931, 95% CI : 1.680, 2.219) and depression (OR = 2.525, 95% CI : 1.936, 3.293) as well as testosterone level (β = 0.083, 95% CI : 0.028, 0.140). Pack-years of smoking and cigarettes per day were positively associated with the prevalence of trouble sleeping and depression as well as testosterone level ( P trend <0.05). The restricted cubic spline model showed linear relationships of cotinine with trouble sleeping, depression, and testosterone. The positive associations of cigarettes per day with trouble sleeping and depression were greater in females than that in males ( P modification <0.05). However, the potential role of sex hormones was not observed in the association of cotinine with trouble sleeping or de...