A Λ -Ir( iii )-phenylquinazolinone complex enhances ferroptosis by selectively inhibiting metallothionein-1

作者：Lu Zhu, Xingyun Wang, Xingyun Wang, Tian Tian, Yanyan Chen, Wenjing Du, Wei Wei, Jing Zhao, Zijian Guo, Xiuxiu Wang, Xiuxiu Wang · 发表于：Chemical Science · 年份：2024 · DOI：10.1039/d4sc00422a · 被引用次数：13 · 研究领域：Ferroptosis and cancer prognosis、Drug Transport and Resistance Mechanisms、RNA modifications and cancer

-IrPPQ achieved precise regulation of ferroptosis in pancreatic cancer cells. This work provides new insights into the design of chiral ferroptosis-inducing metallodrugs for future pancreatic cancer therapy.