The State-of-the-Art Antibacterial Activities of Glycyrrhizin: A Comprehensive Review

作者：Ru-Yi Chen, Jinjin Shi, Yanjun Liu, Jing Yu, C. Li, Fan Tao, Jia-Feng Cao, Guan‐Jun Yang, Jiong Chen · 发表于：Microorganisms · 年份：2024 · DOI：10.3390/microorganisms12061155 · 被引用次数：28 · 研究领域：Pharmacological Effects of Natural Compounds、Phytochemistry and Bioactivity Studies、Phytochemistry and biological activity of medicinal plants

and is a renowned natural herb with a long history of medicinal use dating back to ancient times. Glycyrrhizin (GLY), the main active component of licorice, serves as a widely utilized therapeutic agent in clinical practice. GLY exhibits diverse medicinal properties, including anti-inflammatory, antibacterial, antiviral, antitumor, immunomodulatory, intestinal environment maintenance, and liver protection effects. However, current research primarily emphasizes GLY's antiviral activity, while providing limited insight into its antibacterial properties. GLY demonstrates a broad spectrum of antibacterial activity via inhibiting the growth of bacteria by targeting bacterial enzymes, impacting cell membrane formation, and altering membrane permeability. Moreover, GLY can also bolster host immunity by activating pertinent immune pathways, thereby enhancing pathogen clearance. This paper reviews GLY's inhibitory mechanisms against various pathogenic bacteria-induced pathological changes, its role as a high-mobility group box 1 inhibitor in immune regulation, and its efficacy in combating diseases caused by pathogenic bacteria. Furthermore, combining GLY with other antibiotics reduces the minimum inhibitory concentration, potentially aiding in the clinical development of combination therapies against drug-resistant bacteria. Sources of information were searched using PubMed, Web of Science, Science Direct, and GreenMedical for the keywords "licorice", "Glycyrrhizin", "antibacterial",...