A hemodynamic study of the relationship between the left and right liver volumes and the blood flow distribution in portal vein branches

作者：Chiyu Xie, Shengda Sun, Hao Huang, Xiaofan Li, Wei Qu, Hongqing Song · 发表于：Medical Physics · 年份：2024 · DOI：10.1002/mp.17184 · 被引用次数：6 · 研究领域：Liver Disease and Transplantation、Hepatocellular Carcinoma Treatment and Prognosis、Organ Transplantation Techniques and Outcomes

Abstract Background Cirrhosis patients often exhibit clinical symptoms such as right liver atrophy, portal hypertension, spleen enlargement and increased blood supply, which exhibit considerable variation between the left and right liver sections. These differences are hypothesized to stem from disparities in blood flow within the left and right portal vein (PV) branches. However, rigorous quantitative evidence remains scarce. Purpose We mainly aim at quantitatively revealing the relationship between the blood flow rates of two PV branches and liver volumes, and providing quantitative evidence and theoretical support for the diagnosis and treatment of cirrhosis from the perspective of hemodynamics. Methods Five cirrhotic patients and two healthy volunteers from Beijing Friendship Hospital are investigated. Their PV blood flow models are established based on computed tomography (CT) images and finite volume simulations. The volume of the left and right liver lobes are measured in 3‐matic. The distributions of blood source in the PV branches are tracked by streamline analysis. The blood flow rates are quantitatively counted by integrating the blood source velocities. Linear analysis is performed to build the relationship between liver volumes and PV blood flow distributions. Results Streamline analysis reveals significant differences in blood distribution between the left and right PV branches. The majority of blood from the superior mesenteric vein (SMV) flowed into the right ...