Prodigiosin: unveiling the crimson wonder – a comprehensive journey from diverse bioactivity to synthesis and yield enhancement

作者：Yonglin Lu, D Liu, Renhui Jiang, Ziyun Li, Xueyan Gao · 发表于：Frontiers in Microbiology · 年份：2024 · DOI：10.3389/fmicb.2024.1412776 · 被引用次数：26 · 研究领域：Microbial Metabolism and Applications、Pharmacological Effects of Natural Compounds、Microbial Natural Products and Biosynthesis

Prodigiosin (PG) is a red tripyrrole pigment from the prodiginine family that has attracted widespread attention due to its excellent biological activities, including anticancer, antibacterial and anti-algal activities. The synthesis and production of PG is of particular significance, as it has the potential to be utilized in a number of applications, including those pertaining to clinical drug development, food safety, and environmental management. This paper provides a systematic review of recent research on PG, covering aspects like chemical structure, bioactivity, biosynthesis, gene composition and regulation, and optimization of production conditions, with a particular focus on the biosynthesis and regulation of PG in Serratia marcescens. This provides a solid theoretical basis for the drug development and production of PG, and is expected to promote the further development of PG in medicine and other applications.