Fructose@histone synergistically improve the performance of DNA-templated Cu NPs: rapid analysis of LAM in tuberculosis urine samples using a handheld fluorometer and a smartphone RGB camera

作者：Yanming Meng, Yue Wang, Zixuan Zhan, Yuemei Chen, Chunying Zhang, Peng Wu, Binwu Ying, Piaopiao Chen · 发表于：Journal of Materials Chemistry B · 年份：2024 · DOI：10.1039/d4tb00693c · 被引用次数：7 · 研究领域：Advanced biosensing and bioanalysis techniques、Biosensors and Analytical Detection、Advanced Nanomaterials in Catalysis

. We validated the clinical utility of the biosensor by testing the LAM in the urine of patients. Forty urine samples were tested, with positive LAM results in the urine of 18/20 tuberculosis (TB) cases and negative results in the urine of 6/10 latent tuberculosis infection cases and 10/10 non-TB cases. The assay results revealed a 100% specificity and a 90% sensitivity, with an area under the curve of 0.9. We believe that the NASPI biosensor can be a promising clinical tool with great potential to convert LAM into clinical indicators for TB patients.