Rhodium-Promoted C–H Activation/Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Selection Outcomes

作者：Yuhan Lv, Min Wu, Weiwei Lu, Meiying Cui, Jiaxiang Liu, Wei Yi, Xuan Wang, Xiaojie Lu · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c01553 · 被引用次数：14 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Sulfur-Based Synthesis Techniques

Inspired by previous selection outcomes, we investigated and developed a rhodium-promoted C-H activation/annulation reaction of DNA-linked terminal alkynes and aromatic acids. This reaction exhibits excellent efficiency with high conversions and a broad substrate scope. Most importantly, the unique DEL-compatible conditions provide a better scenario for yielding an isocoumarin scaffold compared to conventional organic reaction conditions, and this newly developed on-DNA method has confirmed its feasibility in preparing DNA-encoded libraries.