Association of methyl donor nutrients dietary intake and sleep disorders in the elderly revealed by the intestinal microbiome

作者：Qianqian Chen, Rui Fan, Lixia Song, Shuyue Wang, Mei You, Meng Cai, Yuxiao Wu, Yong Li, Meihong Xu · 发表于：Food & Function · 年份：2024 · DOI：10.1039/d4fo01303d · 被引用次数：10 · 研究领域：Gut microbiota and health、Amino Acid Enzymes and Metabolism、Polyamine Metabolism and Applications

= 147). Based on the intestinal microbiome, the beta diversity of the intestinal flora was higher in the high methyl-donor nutritional quality (HQ) group compared to the low methyl-donor nutritional quality (LQ) group, and it was lower in the SD group compared to the control group. This suggests that MDNs may regulate sleep by modulating the abundance distribution of the microbiota. Subsequently, we performed correlation analyses between the relative abundance of the microbiota, MDNs intake, and the Pittsburgh Sleep Quality Index (PSQI), identifying five genera with potential regulatory roles. The KEGG pathway analysis indicated that energy metabolism and one-carbon metabolism might be the pathways through which MDNs modulate sleep. This study offers dietary guidance strategies for managing SD in the elderly and provides insights for targeted microbiota intervention.