Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia

作者：Xiang-Shan Yuan, Zhe Xiang, Jian-Bo Jiang, Fang Yuan, Mu-Tian Zhang, Kai‐ying Zhang, Zhao-yi Chen, Wei‐Min Qu, Wensheng Li, Zhi‐Li Huang · 发表于：Cell Discovery · 年份：2024 · DOI：10.1038/s41421-024-00676-x · 被引用次数：11 · 研究领域：Regulation of Appetite and Obesity、Sleep and Wakefulness Research、Circadian rhythm and melatonin

Insomnia, a primary sign of sleep disorders, involves problems with sleep duration and onset. Exposure to intense emotional stimuli before bedtime has been shown to increase sympathetic activity, reduce restorative sleep, and heighten nighttime vigilance in humans 1 . Emotional triggers, such as predators or rewards, can also induce hyperarousal in animals 2 , 3 , indicating that emotional stimuli can lead to insomnia. External environmental stimuli, particularly pheromones, serve as significant triggers for emotional changes in mice, resulting in avoidance, aggressive behaviors, heightened attentiveness, and prolonged arousal time 4 , 5 , 6 . It is widely known that pheromones are relayed through specific neural pathways, including the vomeronasal organ, accessory olfactory bulb, medial amygdala, and bed nucleus of stria terminalis, and integrated into the ventral premammillary nucleus (PMv) 7 . Recent studies have verified that pheromones induce a remarkable increase in the activity of PMv neurons and subsequently lead to aggressive or reproductive behaviors 4 , 8 , 9 . These findings suggest that the PMv is crucial in integrating pheromone inputs and regulating aggressive or reproductive behaviors depending on alertness or wakefulness. However, it’s unclear whether the PMv regulates sleep–wake behavior and contributes to insomnia induced by emotional stimuli.