Advances and prospects in deuterium metabolic imaging (DMI): a systematic review of in vivo studies

作者：Feng Pan, Xinjie Liu, Jiayu Wan, Yusheng Guo, Peng Sun, Xiaoxiao Zhang, Jiazheng Wang, Qingjia Bao, Lian Yang · 发表于：European Radiology Experimental · 年份：2024 · DOI：10.1186/s41747-024-00464-y · 被引用次数：21 · 研究领域：Cancer, Hypoxia, and Metabolism、Radiopharmaceutical Chemistry and Applications、Biochemical and Molecular Research

BACKGROUND: Deuterium metabolic imaging (DMI) has emerged as a promising non-invasive technique for studying metabolism in vivo. This review aims to summarize the current developments and discuss the futures in DMI technique in vivo. METHODS: A systematic literature review was conducted based on the PRISMA 2020 statement by two authors. Specific technical details and potential applications of DMI in vivo were summarized, including strategies of deuterated metabolites detection, deuterium-labeled tracers and corresponding metabolic pathways in vivo, potential clinical applications, routes of tracer administration, quantitative evaluations of metabolisms, and spatial resolution. RESULTS: H3]acetate) were utilized in DMI to detect and quantify different metabolic pathways such as glycolysis, tricarboxylic acid cycle, and fatty acid oxidation. The quantifications (e.g., lactate level, lactate/glutamine and glutamate ratio) hold promise for diagnosing malignancies and assessing early anti-tumor treatment responses. Tracers can be administered orally, intravenously, or intraperitoneally, either through bolus administration or continuous infusion. For metabolic quantification, both serial time point methods (including kinetic analysis and calculation of area under the curves) and single time point quantifications are viable. However, insufficient spatial resolution remains a major challenge in DMI (e.g., 3.3-mL spatial resolution with 10-min acquisition at 3 T). CONCLUSIONS: Enhanci...