A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves

作者：Pengcheng Sun, Chaochao Li, Can Yang, Mengchun Sun, Hanqing Hou, Yanjun Guan, Jinger Chen, Shangbin Liu, Kuntao Chen, Yuan Ma, Yunxiang Huang, Xiangling Li, Huachun Wang, Liu Wang, Shengfeng Chen, Haofeng Cheng, Wei Xiong, Xing Sheng, Milin Zhang, Jiang Peng, Shirong Wang, Yu Wang, Lan Yin · 发表于：Nature Communications · 年份：2024 · DOI：10.1038/s41467-024-49166-4 · 被引用次数：66 · 研究领域：Neuroscience and Neural Engineering、Photoreceptor and optogenetics research、Vagus Nerve Stimulation Research

Optoelectronic neural interfaces can leverage the photovoltaic effect to convert light into electrical current, inducing charge redistribution and enabling nerve stimulation. This method offers a non-genetic and remote approach for neuromodulation. Developing biodegradable and efficient optoelectronic neural interfaces is important for achieving transdermal stimulation while minimizing infection risks associated with device retrieval, thereby maximizing therapeutic outcomes. We propose a biodegradable, flexible, and miniaturized silicon-based neural interface capable of transdermal optoelectronic stimulation for neural modulation and nerve regeneration. Enhancing the device interface with thin-film molybdenum significantly improves the efficacy of neural stimulation. Our study demonstrates successful activation of the sciatic nerve in rodents and the facial nerve in rabbits. Moreover, transdermal optoelectronic stimulation accelerates the functional recovery of injured facial nerves.