Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier

作者：Shuaijie Wang, Yuzhong Yang, Xiaohan Jiang, Xiang Zheng, Qiufang Wei, Wenbin Dai, Xuemei Zhang · 发表于：Cell Death Discovery · 年份：2024 · DOI：10.1038/s41420-024-02043-x · 被引用次数：9 · 研究领域：RNA modifications and cancer、Biochemical and Molecular Research、Amoebic Infections and Treatments

The intestinal lumen acts as a critical interface connecting the external environment with the body's internal state. It's essential to prevent the passage of harmful antigens and bacteria while facilitating nutrient and water absorption. The intestinal barriers encompass microbial, mechanical, immunological, and chemical elements, working together to maintain intestinal balance. Numerous studies have associated m6A modification with intestinal homeostasis. This review comprehensively outlines potential mechanisms through which m6A modification could initiate, exacerbate, or sustain barrier damage from an intestinal perspective. The pivotal role of m6A modification in preserving intestinal equilibrium provides new insights, guiding the exploration of m6A modification as a target for optimizing preventive and therapeutic strategies for intestinal homeostasis.