A combination of faecal and intratumour microbial community profiling reveals novel diagnostic and prognostic biomarkers for pancreatic tumours

作者：Wei Wang, Cheng Qian, Ting Wang, Yuetong Jiang, Yiran Zhou, Kaiyu Liu, Zhiyang Ma, Pengyi Liu, Yichi Wu, Leying Chen, Huaizhi Wang, Tingting Zhou · 发表于：Clinical and Translational Medicine · 年份：2024 · DOI：10.1002/ctm2.1726 · 被引用次数：9 · 研究领域：Pancreatic and Hepatic Oncology Research、Gut microbiota and health、Radiomics and Machine Learning in Medical Imaging

Our findings provide a novel interpretive framework for diagnostic and prognostic biomarkers for pancreatic tumours. A multi-step combination of faecal and intratumour microbial classifiers has the potential to be clinical biomarkers in the early detection of pancreatic cancer, which has less invasiveness, higher sensitivity and specificity. Pancreatic tumours are extremely lethal diseases characterized by difficult early diagnosis and rapid metastasis.1 Histopathological examination of the biopsy specimens of pancreatic tumours obtained by endoscopy or surgery is considered as a gold diagnosis standard of pancreatic tumors.2 Nonetheless, pathological analysis requires very high accuracy in biopsy localization with multiple sampling, and the accuracy of sampling has a significant impact on misjudgment.3 Given diagnostic delays, cancer metastasis and adverse reactions of chemotherapy or radiotherapy, it is urgent to explore new strategies which are required to develop effective diagnostic and treatment options for improving clinical outcomes of pancreatic tumours. As a novel component in shaping the immune system, the microbiome has been increasingly shown to be important in the maintenance of homeostasis in several physiologic processes.4 Here, we used 193 faecal samples (156 patients with different grade of human pancreatic tumours and 37 healthy volunteers) and 362 fresh pancreatic tissues of malignant (PDAC), premalignant (IPMN1 and IPMN2) and benign (SCN) patients from di...