Risk factors for ICU-acquired weakness in sepsis patients: A retrospective study of 264 patients

作者：Jiajiao Liu, Zhaoxia Xu, Shuhong Luo, Yujie Bai, Jian Feng, Fuxiang Li · 发表于：Heliyon · 年份：2024 · DOI：10.1016/j.heliyon.2024.e32253 · 被引用次数：18 · 研究领域：Sepsis Diagnosis and Treatment、Nosocomial Infections in ICU、Trauma, Hemostasis, Coagulopathy, Resuscitation

Background: Sepsis is a common critical illness in intensive care unit (ICU) and an important risk factor for intensive care unit-acquired weakness (ICU-AW). The objective of the study is to analyze the risk factors of ICU-AW in septic patients. Methods: A total of 264 septic patients admitted to the General Hospital of the Western Theater Command from January 2018 to April 2022 were included in this study. The cohort was divided into 2 groups according to the presence or absence of ICU-AW. Clinical characteristics included age, sex, body mass index, length of ICU stay, multiple organ dysfunction syndrome, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), mechanical ventilation time, intubation, tracheotomy, protective constraint, lactic acid, fasting blood glucose, etc. The clinical characteristics of sepsis were evaluated using logistic regression analysis. Results: A total of 114 septic patients suffered ICU-AW during their ICU stay. Multivariate binary logistic regression analysis showed that APACHE Ⅱ score, mechanical ventilation time, protective constraint, and lactic acid were independent risk factors for ICU-AW in septic patients. The areas under the receiver operating characteristic curve (AUCs) were 0.791, 0.740 and 0.812, all P < 0.05, and the optimal cut-off values were 24 points, 5 days and 2.12 mmol/L, respectively. Conclusions: A high APACHE Ⅱ score, long mechanical ventilation time, protective constraint and high lactate concentration are independen...