Development of silver-doped copper oxide and chitosan nanocomposites for enhanced antimicrobial activities

作者：Yasir Anwar, Hisham Faiz Jaha, Mazhar Ul‐Islam, Tahseen Kamal, Sher Bahadar Khan, Ihsan Ullah, Saleh M. Al‐Maaqar, Sameer Ahmed · 发表于：Zeitschrift für Naturforschung C · 年份：2024 · DOI：10.1515/znc-2023-0166 · 被引用次数：8 · 研究领域：Nanoparticles: synthesis and applications、Moringa oleifera research and applications、Advanced Nanomaterials in Catalysis

Abstract Antimicrobial resistance (AMR) has emerged as a significant and pressing public health concern, posing serious challenges to effectively preventing and treating persistent diseases. Despite various efforts made in recent years to address this problem, the global trends of AMR continue to escalate without any indication of decline. As AMR is well-known for antibiotics, developing new materials such as metal containing compounds with different mechanisms of action is crucial to effectively address this challenge. Copper, silver, and chitosan in various forms have demonstrated significant biological activities and hold promise for applications in medicine and biotechnology. Exploring the biological properties of these nanoparticles is essential for innovative therapeutic approaches in treating bacterial and fungal infections, cancer, and other diseases. To this end, the present study aimed to synthesize silver@copper oxide (Ag@CuO) nanoparticles and its chitosan nanocomposite (Chi-Ag@CuO) to investigate their antimicrobial efficacy. Various established spectroscopic and microscopic methods were employed for characterization purposes, encompassing scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Subsequently, the antimicrobial activity of the nanoparticles was assessed through MIC (minimum inhibitory concentration), MBC (minimum bactericidal concentration), and wel...