Causal association between particulate matter 2.5 and Alzheimer’s disease: a Mendelian randomization study

作者：Meijuan Dang, Ye Li, Lili Zhao, Tao Li, Ziwei Lu, Jialiang Lu, Yuxuan Feng, Yang Yang, Fangcun Li, Fan Tang, Xiaoya Wang, Yating Jian, Heying Wang, Lei Zhang, Hong Fan, Guilian Zhang · 发表于：Frontiers in Public Health · 年份：2024 · DOI：10.3389/fpubh.2024.1343915 · 被引用次数：8 · 研究领域：Air Quality and Health Impacts、Glutathione Transferases and Polymorphisms、Health, Environment, Cognitive Aging

Background: Although epidemiological evidence implies a link between exposure to particulate matter (PM) and Alzheimer's disease (AD), establishing causality remains a complex endeavor. In the present study, we used Mendelian randomization (MR) as a robust analytical approach to explore the potential causal relationship between PM exposure and AD risk. We also explored the potential associations between PM exposure and other neurodegenerative diseases. Methods: Drawing on extensive genome-wide association studies related to PM exposure, we identified the instrumental variables linked to individual susceptibility to PM. Using summary statistics from five distinct neurodegenerative diseases, we conducted two-sample MR analyses to gauge the causal impact of PM on the risk of developing these diseases. Sensitivity analyses were undertaken to evaluate the robustness of our findings. Additionally, we executed multivariable MR (MVMR) to validate the significant causal associations identified in the two-sample MR analyses, by adjusting for potential confounding risk factors. Results: < 0.001). A sensitivity analysis supported the robustness of the observed association, thus alleviating concerns related to pleiotropy. No discernible causal relationship was identified between PM and any other neurodegenerative diseases. MVMR analyses-adjusting for smoking, alcohol use, education, stroke, hearing loss, depression, and hypertension-confirmed a persistent causal relationship between PM2.5...