Composite Microgels Loaded with Doxorubicin-Conjugated Amine-Functionalized Zinc Ferrite Nanoparticles for Stimuli-Responsive Sustained Drug Release

作者：Shirisha Bellala, Viswanathan Karthika, Ujwala Guntakanti, Anitha Kowthalam, Sung Soo Han, Madhusudana Kummara, Sreekanth Reddy Obireddy, Wing‐Fu Lai · 发表于：International Journal of Nanomedicine · 年份：2024 · DOI：10.2147/ijn.s448594 · 被引用次数：8 · 研究领域：Nanoparticle-Based Drug Delivery、Hydrogels: synthesis, properties, applications、Electrospun Nanofibers in Biomedical Applications

Purpose: The purpose of this study is to address the need for efficient drug delivery with high drug encapsulation efficiency and sustained drug release. We aim to create nanoparticle-loaded microgels for potential applications in treatment development. Methods: We adopted the process of ionic gelation to generate microgels from sodium alginate and carboxymethyl cellulose. These microgels were loaded with doxorubicin-conjugated amine-functionalized zinc ferrite nanoparticles (AZnFe-NPs). The systems were characterized using various techniques. Toxicity was evaluated in MCF-7 cells. In vitro release studies were conducted at different pH levels at 37 o C, with the drug release kinetics being analyzed using various models. Results: The drug encapsulation efficiency of the created carriers was as high as 70%. The nanoparticle-loaded microgels exhibited pH-responsive behavior and sustained drug release. Drug release from them was mediated via a non-Fickian type of diffusion. Conclusion: Given their high drug encapsulation efficiency, sustained drug release and pH-responsiveness, our nanoparticle-loaded microgels show promise as smart carriers for future treatment applications. Further development and research can significantly benefit the field of drug delivery and treatment development. Keywords: sodium alginate, carboxymethyl cellulose, doxorubicin, zinc ferrite nanoparticles, microgels