Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling

作者：Yu Fu, Manjin Zhang, Bing‐Dong Sui, Feifei Yuan, Wenbo Zhang, Yashuang Weng, Lei Xiang, Can Li, Longquan Shao, Yong You, Xueli Mao, Haitao Zeng, Di Chen, Meijia Zhang, Songtao Shi, Xuefeng Hu · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.94943 · 被引用次数：30 · 研究领域：Reproductive Biology and Fertility、Reproductive System and Pregnancy、Wnt/β-catenin signaling in development and cancer

Our studies reveal a previously unknown association between apoVs and ovarian folliculogenesis and suggest an apoV-based therapeutic approach to improve oocyte function and birth rates in PCOS and aging.