LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance

作者：Huifang Hu, Lei Han, Jiaying Fu, Xuan He, Ji-Feng Tan, Qing-Ping Chen, Jing-Ru Han, Qing‐Yu He · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.95485 · 被引用次数：17 · 研究领域：Cancer-related molecular mechanisms research、RNA modifications and cancer、RNA Research and Splicing

lncRNA LINC00982 can express a new protein PRDM16-DT to function as a novel regulator in cancer metastasis and drug resistance of CRC. Cimicifugoside H-1 can act on the upstream of the PRDM16-DT signaling pathway to alleviate cancer chemoresistance.