PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity

作者：Zu Ye, Chee Ping Ng, Haidong Liu, Qimei Bao, Shengfeng Xu, Dan Zu, Yanhua He, Yixing Huang, Abdul Qader Al-Aidaroos, Ke Guo, Jie Li, Lai Ping Yaw, Qiancheng Xiong, Min Thura, Weihui Zheng, Fenghui Guan, Xiangdong Cheng, Yin Shi, Qi Zeng · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.93127 · 被引用次数：9 · 研究领域：Protein Tyrosine Phosphatases、RNA modifications and cancer、Protein Kinase Regulation and GTPase Signaling

Combining with the knowledge that PRLs have been identified to be involved in mTOR, EGFR and autophagy, here we concluded the physiological role of PRL1/3 in orchestrating the nutrient sensing, absorbing and recycling via regulating macropinocytosis through its lipid phosphatase activity. This mechanism could be exploited by tumor cells facing a nutrient-depleted microenvironment, highlighting the potential therapeutic significance of targeting PRL1/3-mediated macropinocytosis in cancer treatment.