Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition of Tubular CD74-Macrophage Crosstalk

作者：Zhenkai Wu, Bo Deng, Yuqi Shen, Xuezhu Li, Jiaolun Li, Yan Li, Shuai Ma, Yu Pan, Feng Ding · 发表于：International Journal of Biological Sciences · 年份：2024 · DOI：10.7150/ijbs.91237 · 被引用次数：12 · 研究领域：Macrophage Migration Inhibitory Factor、Apelin-related biomedical research、Biochemical Acid Research Studies

mice was attenuated via administration of methyl ester of (S, R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid (ISO-1), an inhibitor of macrophage inhibition factor (MIF) and CD74 binding. Finally, AOAH expression was found positively correlated with estimated glomerular filtration rate while negatively correlated with the degree of renal fibrosis in kidneys of CKD patients. Thus, our work indicates that AOAH protects against kidney injury and fibrosis by inhibiting renal tubular epithelial cells CD74 signaling pathways. Targeting kidney AOAH represents a promising strategy to prevent renal fibrosis progression.