Copper-Catalyzed Asymmetric Kinugasa/Michael Addition Cascade Reactions for the Synthesis of Chiral Spiro β-Lactams

作者：Yun‐Lin Ao, Haowen Ma, Binghan Gan, Wen‐Jing Wang, Jiehao Zhang, Wei Zhou, Xiao‐Qi Zhang, Qian Cai · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c01568 · 被引用次数：13 · 研究领域：Synthesis of β-Lactam Compounds、Click Chemistry and Applications、Synthesis and Catalytic Reactions

A mild copper-catalyzed asymmetric Kinugasa/Michael addition cascade process is developed. The reaction of α, β-unsaturated ester-tethered propiolamides with nitrones provides an efficient protocol for the construction of functionalized chiral 2,6-diazaspiro[3.4]octane-1,5-dione products in satisfactory yields and with high enantio- and diastereoselectivities.